Comparison
Semaglutide vs Tirzepatide
Quick answer
Semaglutide and tirzepatide are both injectable GLP-1 medications for weight loss. Tirzepatide acts on two receptors (GIP and GLP-1) and produces stronger average weight loss in head-to-head trials, while semaglutide has more long-term safety data. Both are available compounded through ZenOryva by prescription.
Semaglutide Single GLP-1 receptor agonist | Tirzepatide Dual GIP + GLP-1 agonist | |
|---|---|---|
| Mechanism | GLP-1 agonist | GIP + GLP-1 dual agonist |
| Average weight loss (clinical trial) | ~15% | ~20-22% |
| Brand-name equivalent | Ozempic / Wegovy | Mounjaro / Zepbound |
| Dosing schedule | Weekly injection | Weekly injection |
| Long-term safety data | Strongest available | Strong, less long-term |
| Common side effects | Mild nausea, GI | Mild nausea, GI |
| ZenOryva starting price | $197 first month | $297 first month |
| Compounded option available |
Choose Semaglutideif…
Best for first-time GLP-1 users, those prioritizing the strongest long-term safety record, and budget-conscious starters.
Learn more →Choose Tirzepatideif…
Best for higher weight loss goals, plateaus on semaglutide, or people seeking the most aggressive evidence-based protocol.
Learn more →Common questions
Can I switch from semaglutide to tirzepatide?
Yes. Your provider can transition you between molecules without restarting from the lowest dose, depending on where you are in titration.
Which has fewer side effects?
Side-effect profiles are similar — both work on GLP-1 receptors. Slow titration is the most important factor for tolerability with either molecule.
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